The Physical Interaction of Cancer cells:Intravastion
Physical Interaction in Cancer Definitions Terminologies Most definitions below will be based on the cancer or metastasis process. Integrin: Cell adhesion transmembrane receptors that serve as extracellular matrix (ECM)-cytoskeletal linkers and transduce biochemical and mechanical signals between cells and their environment. [1] Collagen Crosslinking: Occurs when enzymes like lysyl oxidase (LOX) create chemical bonds between collagen fibers, making the ECM more rigid and densely packed. Focal adhesions: Integrin clusters located at the basal surface of adherent cells that connect the extracellular matrix to the cytoskeleton through focal adhesion proteins. Lamellipodia: Large cytoplasmic projections found primarily at the leading edge of migrating cells, particularly on two-dimensional substrates. Filopodia: Thin finger-like protrusions composed of bundled actin filaments, often extended from the e...